By Dennis J. McCance (Eds.)
This e-book describes up to date details at the pathogenesis and molecular biology of human papillomaviruses and describes the mechanistic position of the viruses in epithelial cancers. incorporated within the e-book are chapters at the epidemiology of human papillomaviruses, the standards that keep an eye on replication and transcription and the viral proteins, that are interested in modulating the biology of the host telephone top to melanoma. information of the immune reaction to the viruses and power vaccine suggestions are discussed. Read more...
summary: This booklet describes updated details at the pathogenesis and molecular biology of human papillomaviruses and describes the mechanistic position of the viruses in epithelial cancers. incorporated within the booklet are chapters at the epidemiology of human papillomaviruses, the standards that keep an eye on replication and transcription and the viral proteins, that are thinking about modulating the biology of the host cellphone resulting in melanoma. information of the immune reaction to the viruses and capability vaccine concepts are mentioned
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Extra resources for Human Papilloma viruses
The DNA around the late promoter became more accessible to DNAseI upon differentiation. This indicates that the chromatin structure over the late promoter becomes transcriptionally accessible at this stage of the life-cycle. Two cellular processes which can mediate chromatin rearrangements, namely histone acetylation by histone acetyltransferases (HATs), and ATP-dependent chromatin remodeling could be involved in altering chromatin structure. While HATs were found to play a role in regulation of early gene expression, these studies indicated that a mechanism other than histone acetylation was responsible for chromatin rearrangement around the late promoter .
Cancer Res 1996; 56: 3967-3974. Vernon SD, Unger ER, Miller DL, Lee DR, Reeves WC. Association of human papillomavirus type 16 integration in the E2 gene with poor disease-free survival from cervical cancer. Int J Cancer 1997. 74: 50-56. Villa LL, Sichero L, Rahal P, Caballero O, Ferenczy A, Rohan T, Franco EL. Molecular variants of human papillomavirus types 16 and 18 preferentially associated with cervical neoplasia. J Gen Viro12000; 81: 2959-2968. Volter C, He Y, Delius H, Roy-Burman A, Greenspan JS, Greenspan D, de Villiers E-M.
Oncogene 2001; 20: 2413-2423. Antson AA, Burns JE, Moroz OV, Scott DJ, Sanders CM, Bronstein IB, Dodson GG, Wilson KS, Maitland NJ. Structure of the intact transactivation domain of the human papillomavirus E2 protein. Nature 2000; 403: 805-809. Apt D, Chong T, Liu Y, Bernard HU. Nuclear factor I and epithelial cell-specific transcription of human papillomavirus type 16. J Virol 1993; 67: 4455-4463. Apt D, Watts RM, Suske G, Bernard HU. High Spl/Sp3 ratios in epithelial cells during epithelial differentiation and cellular transformation correlate with the activation of the HPV-16 promoter.
Human Papilloma viruses by Dennis J. McCance (Eds.)