Download e-book for kindle: Hepatotoxicity: From Genomics to In Vitro and In Vivo Models by Saura C. Sahu

By Saura C. Sahu

ISBN-10: 0470057165

ISBN-13: 9780470057162

ISBN-10: 0470516747

ISBN-13: 9780470516744

This publication addresses the entire present, up to date advancements during this clinical self-discipline. Liver is the executive metabolizing web site within the physique, and hence, it's a significant objective organ for drug and chemical toxicity. accordingly, hepatotoxicity is a vital endpoint within the safeguard overview of substances and chemical compounds. Contributions from best investigators in hepatotoxicity learn handle present advancements during this medical self-discipline and talk about use of present leading edge know-how similar to microarrays in hepatotoxicity hence offering a greater knowing of hepatotoxins, their interactions and mechanisms of motion. This useful authoritative resource of data is the 1st e-book to deal with this subject for almost ten years, making it a vital source for readers from a variety of disciplines similar to toxicology, pharmacology, hepatology, drug toxicity and nutrients technology.

Show description

Read or Download Hepatotoxicity: From Genomics to In Vitro and In Vivo Models PDF

Best digestive organs books

Glutamine - A Medical Dictionary, Bibliography, and - download pdf or read online

This can be a 3-in-1 reference e-book. It supplies a whole clinical dictionary protecting enormous quantities of phrases and expressions in relation to glutamine. It additionally supplies large lists of bibliographic citations. eventually, it presents info to clients on tips to replace their wisdom utilizing a variety of web assets.

Integrative Gastroenterology (Weil Integrative Medicine by Gerard Mullin PDF

Digestive lawsuits became more and more universal. contemporary information exhibit that gastrointestinal court cases account for almost a 3rd of all visits to fundamental care medical professionals and that just about one in six americans be afflicted by digestive sickness. during this quantity, a world panel of best specialists presents a wealth of data for wellbeing and fitness care practitioners and shoppers at the motive, equipment, modalities, and efficacy of integrative options for gastrointestinal issues.

Samuel S. Lee, Richard Moreau's Cirrhosis : a practical guide to management PDF

Cirrhosis: a pragmatic consultant to administration presents gastroenterologists and hepatologists with an updated medical consultant providing the superior evidence-based perform within the prognosis, therapy and administration of liver cirrhosis and its many complications.  Designed to supply sensible assistance continually, it presents medical professionals with an incredibly useful gizmo within the scientific environment, with every one bankruptcy that includes diagnostic/management algorithms, key issues and different pedagogic beneficial properties.

Download e-book for kindle: Alcoholic and Non-Alcoholic Fatty Liver Disease: Bench to by Naga Chalasani, Gyongyi Szabo

This quantity is the 1st textual content to concisely but comprehensively hide advancements for either alcoholic and nonalcoholic fatty liver disorder in an geared up style. points of those ailments coated within the publication contain worldwide epidemiology and possibility elements, pathogenesis, animal versions, hepatic and extra-hepatic malignancies, therapy versions, and present and rising cures.

Extra resources for Hepatotoxicity: From Genomics to In Vitro and In Vivo Models

Example text

Ten ml of diluted Percoll (30 vol %) were placed in the bottom of each tube and centrifuged at 1100 × g for 5 min. The pellets were washed with Williams E at 30 × g for 2 min and then resuspended in 20 ml Williams E solution. Viability of the isolated hepatocytes used in these studies was typically greater than 90 %. 35 mg/ml) to a final cell density of 4 × 105 cells/ml and plated in 12 (1 ml) or 6 (2 ml) well plates, as previously indicated for rat hepatocytes (Davila and Morris, 1999). 3 Cell Culture Treatment Hepatocytes were treated for two consecutive days at 24 h and 48 h after initial plating with optimal concentrations of phenobarbital, PB (100 μM), rifampicin, RIF (10 μM), 3-methylcholanthrene, 3MC (1 μM), clofibrate, CLO (50 μM), tamoxifen (TAM, 10 μM), omeprazole (OMZ, 20 μM), pregnenolone-16α-carbonitrile (PCN, 1 μM) and hydrocortisone (HC, 20 μM).

As a result, ultimate in vitro/in vivo correlation of these systems remains a challenge for their widespread use and adoption for assessing hepatotoxicity. 5 Other Cell Lines and Engineered Cellular Systems In addition to the cellular systems mentioned above, several other cell lines have been used, although not as widespread, to address mechanisms of hepatotoxicity. , 1997). Continued evaluation and testing of these cell lines will be a critical step for the acceptance of these as viable reagents to predict toxic events in the liver.

2005). Markers identified were mainly markers of early hepatic differentiation. , 2005). The lack of cytokeratin expression would suggest that the cells remained mesenchymal and did not fully differentiate into an epithelial cell type such as a parenchymal hepatocyte. , 2006). 2 Embryonic Stem Cell-Derived Hepatocytes It might seem that the derivation of hepatocytes from embryonic stem (ES) cells might be the major focus of researchers trying to generate hepatocytes from stem cells. However, this is not the case.

Download PDF sample

Hepatotoxicity: From Genomics to In Vitro and In Vivo Models by Saura C. Sahu


by Kevin
4.2

Rated 4.39 of 5 – based on 33 votes

About admin