By Charles R. Scoggins, Chandrajit P. Raut, John T. Mullen
This textbook presents a finished, state-of-the-art evaluate of this box, and should function a necessary source for clinicians, surgeons and researchers with an curiosity in GIST. The publication stories new information approximately danger elements for the disorder, profiles the hot staging process for GIST, highlights our present figuring out of genetic mutations that bring about GIST, and gives new views approximately imaging of GIST tumors. For localized illness, a better appreciation of organ-sparing techniques and the significance of renovation of gastrointestinal functionality is mentioned intimately, and advances in surgical suggestions are highlighted, together with minimally invasive surgical procedure. For metastatic illness, the molecular biology of GIST is reviewed in an in depth and comprehensible demeanour, together with the knowledge that has fostered novel distinctive techniques that experience revolutionized administration. numerous landmark trials were released within the previous couple of years and are positioned in context with recognize to present administration. Integration of surgical procedure and systemic remedy via consolidative methods has yielded provocative info that gives you to extra develop the sphere, and significant advances during this area also are mentioned. Gastrointestinal Stromal Tumors: Bench to Bedside will function a really resource for physicians and researchers facing, and attracted to, this tough malignancy. It offers a concise but entire precis of the present prestige of the sector that might aid advisor sufferer administration and stimulate investigative efforts. All chapters are written by way of specialists of their fields and comprise the freshest clinical and medical info.
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Extra resources for Gastrointestinal Stromal Tumors: Bench to Bedside
Arch Pathol Lab Med. 2012;136:483–9. 77. Carney JA. Carney triad: a syndrome featuring paraganglionic, adrenocortical, and possibly other endocrine tumors. J Clin Endocrinol Metab. 2009;94:3656–62. 78. Agaram NP, Wong GC, Guo T, Maki RG, Singer S, DeMatteo RP, et al. Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors. Genes Chromosomes Cancer. 2008;47:853–9. 79. Agaimy A, Terracciano LM, Dirnhofer S, Tornillo L, Foerster A, Hartmann A, et al. V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wildtype gastrointestinal stromal tumours.
They respond poorly to imatinib, but many second- and third-generation tyrosine kinase inhibitors such as sunitinib, sorafenib, and dasatinib have greater efficacy [56, 75, 76]. Furthermore, the commonly used standard risk-stratification system (based on tumor site, tumor size, and mitotic index) for predicting malignant potential in GIST fails to predict clinical behavior for SDH-deficient tumors; thus it should not be applied [17, 56, 58]. Identifying SDH-deficient GIST also identifies a subset of patients who benefit from germline testing for SDH mutations and long-term clinical follow-up for the detection of the other aforementioned syndromic tumors [75, 77].
Extragastrointestinal (soft tissue) stromal tumors: an analysis of 48 cases with emphasis on histologic predictors of outcome. Mod Pathol. 2000;13:577–85. 13. Yamamoto H, Oda Y, Kawaguchi K, Nakamura N, Takahira T, Tamiya S, et al. c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue). Am J Surg Pathol. 2004;28:479–88. 14. Prakash S, Sarran L, Socci N, DeMatteo RP, Eisenstat J, Greco AM, et al. Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature.
Gastrointestinal Stromal Tumors: Bench to Bedside by Charles R. Scoggins, Chandrajit P. Raut, John T. Mullen