By Novartis Foundation
This crucial publication covers the constitution and molecular biology of small around based viruses (SSRVs) akin to caliciviruses and astroviruses, and the fundamental pathology of an infection. It offers readers with the information had to make development within the prevention and therapy of those infections. Readers also will locate an outline of gastroentitis vaccines, their constitution and molecular biology, in addition to the fundamental pathology of an infection, epidemiology and surveillance.* presents an interdisciplinary technique, supplying contributions from uncomplicated and medical learn* Discusses the prevention and remedy of regimes* contains an summary of gastroentitis vaccines
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Additional resources for Gastroenteritis Viruses
Semin Virol2:39-53 Rosen BI, Fang 2-Y, Glass RI, Monroe SS 2000 Clonmg of human picorbmavirus gene segments and development of an RT-PCR detection assay. Virology 277:316-329 Saif LJ, Jiang B 1994 Non group A rotaviruses of humans and animals. Curr Top Microbiol Immunoll85:33P-371 Schaub SA, Oshiro RK 2000 Public health concerns about caliciviruses as waterborne contaminants. J Infect Dis (suppl2) 181:S374-S380 Slutsker L, &es AA, Greene KD, Wells JG, Hutwagner L, Griffin PM 1997 Escberzcbza culi 0157:H7 diarrhea in the United States: clinical and epidemiologic features.
Our recent structural studies to probe further the genomic organization by varying pH and ionic concentrations have shown that hydrogen bond interactions between internal proteins and RNA, and the electrostatic interactions between the RNA strands, are important for proper genome organization (B. Pesavento, J. Lawton, M. K. Estes, B. V. V. Prasad 2000, unpublished results). This question is particularly relevant because it has been shown that 2/6-VLPs can confer protective immunity in mice (O’Neal et a1 1998), and also that anti-VP6 IgA molecules can protect mce from rotavirus infection (Bums et a1 1996).
VP7, which constitutes the outer layer, clusters into trimers surrounding the channels. Each particle has 260 trimers or 780 molecules of VP7. There are 60 spikes, located at one edge of the type I1 channels, in each particle. Our structural analysis using anti-VP4 monoclonal antibodies (MAb) has shown that the spikes are made up of VP4 (Piasad et a1 1990). Two molecules of the Fab bind on either side of the bi-lobed head of each spike. VP4 has been implicated in cell entry, neutralizatjon, virulence, and in some animal viruses it is a haemagglutinin (reviewed in Estes 1996).
Gastroenteritis Viruses by Novartis Foundation