By Per Svenningsson, Angus C. Nairn, Paul Greengard (auth.), Dr. Rao S. Rapaka, Dr. Wolfgang Sadée (eds.)
Drug dependancy: From simple study to Therapy
Drug dependancy: From simple study to Therapyoffers a finished evaluate of physiological, biochemical, genetic and behavioral pathways underlying drug habit. targeting basic neurophysiological approaches that overlap among drug habit and different CNS issues, this quantity covers the interpretation of uncomplicated examine into novel cures, not just of drug habit yet a spectrum of similar CNS issues, together with soreness. Chapters are written by way of major scientists with commonly ranging services in man made and computational chemistry, molecular biology, genetics, neurosciences, drug discovery and improvement, drug concentrating on, and quantitative therapeutics, offering an remarkable assessment of a posh box of excessive societal signficance.
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45,46 Rosuvastatin calcium (19, Crestor, AstraZeneca, 2003), an inhibitor of 3-hydroxy3-methylglutaryl coenzyme A (HMG-CoA) reductase and a derivative of mevastatin isolated from Penicillium citrinum and P. 47 Like other available HMG-CoA reductase inhibitors (atrovastatin, fluvastatin, lovastatin, pravastatin, and simvastatin), rosuvastatin competitively inhibits the rate-limiting step in the formation of endogenous cholesterol by HMG-CoA reductase. 49 Daptomycin (20, Cubicin, Cubist, 2003) is a cyclic lipopeptide antibacterial agent derived from Streptomyces roseosporus, which has been approved for the treatment of complicated skin and skin structure infections (cSSSIs).
59 Thus, consistent with the cellular localization of its receptor, the µ-opioid receptor agonist, DAMGO, inhibits the increase in DARPP-32 phosphorylation induced by SKF 81,297, a D1 receptor agonist, but not by CGS 21,680, an A2A receptor agonist. Conversely, the δ-opioid receptor agonist, DPDPE, inhibits DARPP-32 phosphorylation induced by activation of A2A receptors, but not by activation of D1 receptors. 65 Using a variety of pharmacological reagents, nicotine at a low concentration (1 µM) has been found to stimulate α4β2-containing nAChRs at dopaminergic terminals.
Cefditoren has a broad spectrum of activity against both Gram-positive and Gram-negative bacteria, and is stable to hydrolysis in the presence of a variety of β-lactamases. 54 Caspofungin acetate (24, Cancidas, Merck, 2001) is a semisynthetic lipopeptide derived from pneumocandin B0, a fermentation product of Glarea lozoyensis. It inhibits the synthesis of the glucose homopolymer β-(1,3)-D-glucan, which is an essential component of the cell wall of many fungi but is absent in mammals. 58 Pimecrolimus (26, Elidel, Novartis, 2001) is a novel analog of ascomycin, isolated as a fermentation product of Streptomyces hygroscopicus var ascomyceticus.
Drug Addiction: From Basic Research to Therapy by Per Svenningsson, Angus C. Nairn, Paul Greengard (auth.), Dr. Rao S. Rapaka, Dr. Wolfgang Sadée (eds.)