Download e-book for iPad: Comprehensive Medicinal Chemistry II, Volume 2 : Strategy by David J Triggle, John B Taylor

By David J Triggle, John B Taylor

ISBN-10: 0080445136

ISBN-13: 9780080445137

The 1st variation of entire Medicinal Chemistry used to be released in 1990 and was once rather well bought. accomplished Medicinal Chemistry II is far greater than an easy updating of the contents of the 1st version. thoroughly revised and increased, this new version has been refocused to mirror the numerous advancements and adjustments over the last decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and extra. The content material includes the main updated, authoritative and complete reference textual content on modern medicinal chemistry and drug learn, protecting significant healing periods and goals, learn process and agency, high-throughput applied sciences, computer-assisted layout, ADME and chosen case histories. it's this assurance of the method, applied sciences, ideas and purposes of medicinal chemistry in one paintings that may make finished Medicinal Chemistry II a distinct paintings of reference and a unmarried element of access to the literature for pharmaceutical and biotechnology scientists of all disciplines and for lots of executives as well.Also on hand on-line through ScienceDirect (2006) - that includes large looking, looking out, and inner cross-referencing among articles within the paintings, plus dynamic linking to magazine articles and summary databases, making navigation versatile and simple. for additional information, pricing ideas and availability stopover at www.info.sciencedirect.com. * Comprehensively reports - the recommendations, applied sciences, ideas and purposes of contemporary medicinal chemistry * presents a world and present standpoint of trendy drug discovery procedure and discusses the main healing periods and goals* encompasses a certain number of case stories and private assays reviewing the invention and improvement of key medicines

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A) Schematics of the screen. Compounds were transferred from library plates to assay plates (containing growth medium, rapamycin, and yeast cells) by using 384-pin arrays. SMER, small-molecule enhancers of rapamycin. (b) Retest of SMIRs in a 384-well plate. White wells indicate compound-induced yeast growth in the presence of rapamycin; black (transparent) wells indicate no growth. (c) Chemical structures of the fast-acting SMIRs (yeast growth indentifiable on day 1, same as the ‘no rapamycin’ control).

135 In the 1990s, the number of billion dollar drugs rose from six to 35. During this period, worldwide sales of the top drug increased from $2 billion to almost $6 billion, and by 1999 the 100th largest selling drug raked in almost $500 MM. However, although antiulcer drugs dominated the top spots, there were more cardiovascular drugs in the top 10 in the 1990s than any other drug class. 138 Some have argued that starting with an old drug is the best way to find a new drug. This has been called selective optimization of side activities (SOSA).

A) Schematics of the screen. Compounds were transferred from library plates to assay plates (containing growth medium, rapamycin, and yeast cells) by using 384-pin arrays. SMER, small-molecule enhancers of rapamycin. (b) Retest of SMIRs in a 384-well plate. White wells indicate compound-induced yeast growth in the presence of rapamycin; black (transparent) wells indicate no growth. (c) Chemical structures of the fast-acting SMIRs (yeast growth indentifiable on day 1, same as the ‘no rapamycin’ control).

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Comprehensive Medicinal Chemistry II, Volume 2 : Strategy and Drug Research by David J Triggle, John B Taylor


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