John H. Scholefield, Cathy Eng's Colorectal Cancer: Diagnosis and Clinical Management PDF

By John H. Scholefield, Cathy Eng

ISBN-10: 0470674806

ISBN-13: 9780470674802

Colorectal melanoma: prognosis and medical Management presents colorectal surgeons, gastroenterologists and oncologists with an authoritative, useful advisor to top perform within the analysis and scientific administration of colorectal cancer.

Covering all different types of therapy together with surgical procedure, chemotherapy and radiotherapy, it examines a number of the new and rising remedies, new techniques for screening and prevention, in addition to the most recent counsel at the such a lot demanding and debatable facets of coping with colorectal cancer.

The authors current vital details on:

  • Controversies in adjuvant chemotherapy
  • Long as opposed to brief direction radiotherapy
  • Minimally invasive surgical procedure and robotics
  • Radical colonic resection

Each bankruptcy includes key issues, advice and methods and scientific case reviews to assist quick searching and information of the fundamental rules, whereas self-assessment questions let readers to check their medical knowledge.

With major overseas surgeons, gastroenterologists and oncologists combining to provide their substantial wealth of workmanship and information, Colorectal Cancer is a well-balanced, integral source for all these concerned about colorectal melanoma management. 


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Extra resources for Colorectal Cancer: Diagnosis and Clinical Management

Example text

Guaiac based faecal occult blood testing (gFOBT) For many years the technology for detecting blood in faeces relied on the indirect guaiac test. Guaiac reacts with haem by means of its ability to detect peroxidase and is not capable of detecting the degradation products of haem [9]. In addition, when haem is introduced into the gastrointestinal tract, it is modified by microflora thus losing its peroxidase activity. Because of this, guaiac tests rarely detect dietary haem and for the same reason they are more sensitive for bleeding lesions in the colon than in the upper gastrointestinal tract.

This is presumably associated with the quality of colonoscopy; bowel preparation is often poorer in the right colon than the left colon and adenomas in the right colon are often flat and subtle when compared with the polypoid lesions seen more commonly on the left. This again emphasises the importance of quality in colonoscopy, and in a study from Germany examining interval cancers occurring 1–10 years after negative colonoscopy, there was a strong association between incompleteness of colonoscopy and the occurrence of interval cancer [55].

N Engl J Med 1996 Jan 11; 334(2): 82–7. 19 Atkin WS, Morson BC, Cuzick J. Long-term risk of colorectal cancer after excision of rectosigmoid adenomas. N Engl J Med 1992 Mar 5; 326(10): 658–62. 20 Imperiale TF, Ransohoff DF. Risk for colorectal cancer in persons with a family history of adenomatous polyps: a systematic review. Ann Intern Med 2012 May 15; 156(10): 703–9. 21 von HS, Picelli S, Edler D, Lenander C, Dalen J, Hjern F, et al. Association studies on 11 published colorectal cancer risk loci.

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Colorectal Cancer: Diagnosis and Clinical Management by John H. Scholefield, Cathy Eng

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