By R. Schindler (auth.), Mrs. Rosemarie Schindler (eds.)
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Additional info for Ciclosporin in Autoimmune Diseases: 1st International Symposium, Basle, March 18–20, 1985
The various pharmacological effects of ciclosporin nali aetivates the T eelIs from the G o phase of the celI eyde and leads these celis to express, 6 to 12 h later, receptors for IL-2 (interleukin 2 or T eelI growth factor) . This receptor expression, indueed by antigen or mitogen, is ealied stage 1 of T cell aetivation (Fig. 3). 2 and 3). This is the second signal required for the T eell to beeome aetivated and to be indueed to produee IL- 25 The Mechanism of Action ofCidosporin: A Continuing Puzzle Fig.
A) Interaction at the level of the iymphocyte membrane CyA binds to eell membranes, but until now no speeifie reeeptor protein has been demonstrated. Saturable and reversible binding oflabelIed CyA oeeurs on the lymphoeytie membrane, the binding sites having a KD of'about 10-7 M . Inaetive 27 eongeners do not displace bound CyA. However, the binding of CyA to membranes is not limited to lymphoeytes. Similar binding eharaeteristies are shown for maerophages, granulocytes, erythroeytes, hepatoeytes and other eells [37, 50].
Thivolet J, Barthelemy H, Rigot-Muller G, Bendelae A (1985) EtTeets of cyclosporin on bullous pemphiloid and pemphigus. Laneet 1:334 13. Wiek G, Muller PU, Sehwarz S (1982) EtTeet of eyclosporin A on spontaneous autoimmune thyroiditis of obese strain (OS) ehiekens. Eur J Immuno112:877 Pharmacokinetics and Interactions of Ciclosporin P. A. Keown, C. R. Stiller, M. Stawecki, J. McMichael and W. Howson Cielosporin (CyA) is a potent immunosuppressive agent which acts selectively upon the immune response by inhibition of the lymphokine cascade, thus inhibiting cell-cell communication [I].
Ciclosporin in Autoimmune Diseases: 1st International Symposium, Basle, March 18–20, 1985 by R. Schindler (auth.), Mrs. Rosemarie Schindler (eds.)