Download e-book for iPad: Chemotherapy. Proceedings of the 7th International Congress by M. Adolphe

By M. Adolphe

ISBN-10: 0080232000

ISBN-13: 9780080232003

Advances in Pharmacology and Therapeutics, quantity 10: Chemotherapy covers the court cases of the seventh foreign Congress of Pharmacology. The name offers papers that element the development of pharmacological learn in chemotherapy.
The textual content first covers the chemotherapy of schistosomiasis. subsequent, the choice offers the developments in malaria and melanoma chemotherapy, besides their pharmacological learn. The textual content additionally information using telephone cultures as instruments in pharmacological investigations.
The booklet may be of significant curiosity to pharmacologists and oncologists.

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Additional info for Chemotherapy. Proceedings of the 7th International Congress of Pharmacology, Paris, 1978

Sample text

R0 11-3128 6 ) Among the benzodiazoprine-derivatives the Roche-compound R0 11-3128 showed an interesting activity in experimental schistosomiasis (Stohler (c)). It was effective against S^mansoni and Sj, haematobium in mice and hamsters. After a single oraI~S3mïnïsEration~ERê"CDgô"In" S1^mansoni infected mice was found to be 80 - 90 mg/kg. In Cebus mônEëys~and baboons infected with S^mansoni and baboons infected with S^haematobium a single oral 35se~3f~25 mg/kg was curative. s · j3aiônlçum"n"hi other hand was refractory to treatment.

The two most important complaints were dizziness and somnolence, both of which were related to the dose of medication. Thus, the frequency of these two side-effects was, respectively, 48% and 31% with a dose of 15mg/kg. Generally, they appeared about two Clinical experience with oxamniquine 31 or three hours after ingestion of the drug and disappeared on the same day. Additionally they were of slight intensity but could develop to moderate intensity. In some patients who took the medication after meals there was a little better tolerance to oxamniquine.

In the patients in this study, the range of peak serum concentrations of drug following the first dose is similar to that observed in Brazilian patients and South African patients. Furthermore, the areas under the serum concentration versus time curves are similar. Thus exposure to drug of the parasites in East Africa, South Africa and Brazil differs only in the duration which resultsfrom multiple dosing. Thus the need for two doses for good efficacy in East Africa is probably a consequence of lower susceptibility of the East African parasite.

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Chemotherapy. Proceedings of the 7th International Congress of Pharmacology, Paris, 1978 by M. Adolphe


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