By Tag E Mansour; Joan MacKinnon Mansour
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Additional resources for Chemotherapeutic targets in parasites : contemporary strategies
Oxygen, when used as an electron acceptor, is not involved in energy conservation. The organisms catabolize carbohydrates in a basically fermentative fashion (irrespective of whether oxygen is present or not). Glycolysis is central to this process, which yields organic acids and alcohols as major end products (1). The pathways of carbohydrate catabolism in E. histolytica, G. lamblia and T. vaginalis are depicted in Figs. 3. The glycolytic sequences themselves are classical in the sense that glucose is catabolized to pyruvate, but there are several features that distinguish the pathways from that operating in most eukaryotes.
J. (1987) Products of Leishmania braziliensis glucose metabolism: release of o-lactate and, under anaerobic conditions, glycerol. Proc. Natl. Acad. Sci. USA 84: 7129-7133. 13. Darling, T. , Davis, D. , London, R. E. and Blum, J. J. (1989) Carbon dioxide abolishes the reverse pasteur effect in Leishmania major promastigotes. Mol. Biochem. Parasitol. 33: 191-202. 14. Keegan, F. , Sansone, L. and Blum, J. J. (1987) Oxidation of glucose, ribose, alanine and glutamate by Leishmania braziliensis panamensis.
It is not clear why only the Kinetoplastida have part of their glycolytic pathway sequestered inside an organelle. Glycosomes have not been detected in any other protists. 1). T. brucei bloodstream form is among the most actively glycolizing cells ever described, though it devotes only 9% of its total cellular protein to the pathway (26). Compartmentation of glycolysis allows the concentrations of glycolytic enzymes, intermediates and cofactors to be sufficiently high and allows the enzymes to be completely saturated (26,58).
Chemotherapeutic targets in parasites : contemporary strategies by Tag E Mansour; Joan MacKinnon Mansour