Read e-book online Chemotactic Factors, Neuropeptides, and Other Ligands for PDF

By Oppenheim J.J., Howard O.M.Z., Goetzl E.

This introductory evaluate serves to introduce the reader to numerous households of mobile chemoattractants together with cytokines referred to as chemokines, as neuropeptides, parts of the supplement cascade, and cyclooxygenase pathways. those ligands percentage the ability to make use of seven transmembrane (STM) G protein-coupled receptors. As is right of alternative cyto-kines, those ligands are multifunctional and, as well as mobilizing inflammatory cells to websites of an infection and harm, act on a large spectrum of progenitor cells and on nonleukocytes. hence, a few of these ligands perform fetal improvement, others on hematopoiesis on trafficking and homing of cells to tissues and organs, at the induction of inflammatory and immune responses, and on regulating cellphone adhesion and angiogenesis. we are going to additionally assessment experiences that quite a few viruses and microorganisms have tailored and discovered to avoid those mediators of host safeguard by means of generating agonists or antagonists or, as illustrated by means of HIV-1, through the use of chemokine receptors as access websites for mobile invasion.

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Chemotactic Factors, Neuropeptides, and Other Ligands for Seven Transmembrane Receptors by Oppenheim J.J., Howard O.M.Z., Goetzl E.

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