's Chemistry of Heterocyclic Compounds: The Pyridazines, PDF

ISBN-10: 0470187972

ISBN-13: 9780470187975

ISBN-10: 0471251372

ISBN-13: 9780471251378

This new quantity considerably updates the unique pyridazines quantity which was once released in 1973. saying the most recent quantity within the winning and favorite Chemistry of Heterocyclic Compounds Series.Content:
Chapter 1 fundamental Syntheses from Aliphatic or Carbocyclic Synthons (pages 1–58):
Chapter 2 basic Syntheses from different Heterocyclic platforms (pages 59–130):
Chapter three Pyridazine, Alkylpyridazines, and Arylpyridazines (pages 131–176):
Chapter four Halogenopyridazines (H 219) (pages 177–250):
Chapter five Oxypyridazines (H 23) (pages 251–322):
Chapter 6 Thiopyridazines (H 755) (pages 323–342):
Chapter 7 Nitro?, Amino?, and comparable Pyridazines (H 463, 629) (pages 343–386):
Chapter eight Pyridazinecarboxylic Acids and comparable Derivatives (H353, 407) (pages 387–433):

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Extra resources for Chemistry of Heterocyclic Compounds: The Pyridazines, Supplement 1, Volume 57

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2 h: 89%). Ixo3 Also other examples. '838 Buta-1,3-diene (190, R = H) or its 2,3-dimethyl derivative (190, R = Me) and p-chlorobenzenediazocy anide gave 2-p-chlorophen yl- 1,2,3,6-tetrahydro-I-pyridazinecarbonitriile (191, R = H) (neat, 25", 5 days: 85%) or its 4,5-dimethyl derivative (191, R =Me) (neat, IOO", 3 h: 90%), respectively;48"621 some kinetic work on such reactions has been reported. 1 1. 427 Dinitrogen tetroxide will also act as an N 1-N2 synthon with appropriate dimethylene compounds.

364 2-Phenylhydrazonomalononitrile(253) and malononitrile gave 4-amino-6imino-l-phenyl-l,6-dihydro-3,5-pyridazinedicarbonitrile (254) (pyridine, reflux, 10 h: 80%). Also other examples in the foregoing references and elsewhere. 4 Where the Two-Atom Synthon Provides C4 -I- C5 This potentially large category of syntheses is represented by very few examples. 3-diphenyi-2-azetidinone(258) (60%). 3 By using two 3-Atom Synthons Because of the symmetry of pyridazine, there can be only two possibilities within this category: an N-N-C synthon plus a C-C-C synthon or two N-C-C synthons (which may be the same or different).

Also other examples in the foregoing references and elsewhere. '696 3-Benzoyl-2-phenylpropionicacid (168) and methylhydrazine gave 2methyl-4,6-diphenyl-4,5-dihydro-3(2H)-pyridazinone(169) (BuOH, reflux, 6 h: 45%) and then its didehydro analogue (Brz, AcOH, 70°,3 h: 93%). 1082 0 0 YN Ph From Two Synthons 31 Levulinic acid (4-oxovaleric acid) and phenylhydrazine gave 6-methyl-2phenyl-4,5-dihydro-3(2H)-pyridazinone(neat, reflux or 170". ~%*~~' Also other examples in the foregoing references and elsewhere.

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Chemistry of Heterocyclic Compounds: The Pyridazines, Supplement 1, Volume 57


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