By Takashi Sugimura (auth.), Hideya Endo, Tetsuo Ono, Takashi Sugimura (eds.)
During the decade a substantial physique of information has come into life touching on a category of carcinogenic molecules mainly represented through 4-nitroquinoline i-oxide. unique papers in this topic are various and largely scattered over many branches of technology; it used to be felt that those papers might be reviewed and the information introduced jointly in a single quantity sooner than it grew to become too unwieldy. This we've got tried to do during this monograph. Our goal has been to incorporate all correct papers released to this point, in order that it could actually function an epitome of the current prestige of information in this vital topic. we now have been lucky in securing the cooperation of a number of colleagues who've contributed chapters, every one facing one point of the topic. now we have been doubly lucky in that those individuals, like ourselves, have been at one time or one other participants of the crowd belonging to the medical employees of Dr. WARO NAKA HARA, Director of the nationwide melanoma middle learn Institute, Tokyo, Japan.
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Extra resources for Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide
4-nitropyridine 1-oxide (5 mM). b In tryptophane solution. Solid line: tryptophane (25 mM) + 4-nitroquinoline 1-oxide (5 mM) vs. 4-nitroquinoline 1-oxide (5 mM). Broken line: tryptophane (25 mM) + 4-nitropyridine 1-oxide (5 mM) vs. 4-nitropyridine 1-oxide (5 mM) quinoline l-oxide-tryptophan system, and it was far stronger than that of the 4-nitropyridine l-oxide-tryptophan: system (Fig. 6 b). The band was regarded as due to the charge transfer from albumin or amino acids to 4-nitroquinoline I-oxide, and an inverse relationship between the equilibrium constants K of the complex formation and the energies of the highest occupied molecular orbitals seemed to support this presumption (Table 6).
This finding together with the evidence presented by TAKAYAMA (1960), that a single application of this compound to mouse skin could induce cancer, suggests that cancer initiation may occur for only a very short time after application. On the specificity of the carcinogenic action of 4-nitroquinoline 1-oxide, LACASSAGNE, Buu-HoI and ZAJDELA (1961) reported that the painting of this compound on mouse skin resulted in tumor formation in one strain but not in others originated from the same parent, while both strains proved to have same susceptibility to 3,4-benzpyrene.
B) Photodynamic Action of 4-Nitroquinoline 1-0xide and Related Compounds on Nucleic Acids In view of the photodynamic action of 4-nitroquinoline I-oxide and related compounds on Paramecium candatum, it may be useful to know the effects of quinoline compounds on DNA upon photoirradiation. A recent experiment by KODAMA and NAGATA (1967) has demonstrated the photodynamic action of 4-nitroquinoline I-oxide on DNA. The effect of photoirradiation was seen only on the guanine residue, while other bases were completely intact (Table 8).
Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide by Takashi Sugimura (auth.), Hideya Endo, Tetsuo Ono, Takashi Sugimura (eds.)