McFadden G., Moyer R.'s CC Chemokine of Molluscum Contagiosum Virus PDF

By McFadden G., Moyer R.

Virus-encoded individuals of the chemokine superfamily of ligands were came across within the genomes of yes poxviruses and herpesviruses. The MC148R gene of molluscum contagiosum virus, a human-specific poxvirus that induces benign pores and skin lesions which may develop into clinically severe in immunocompromised sufferers, encodes for amemberof theCCchemokinesuperfamily which could antagonize the actions of a number of human CC chemokines established. The MC148R protein lacks convinced amino acid motifs on the N-terminus which are believed to be required for signaling from cognate chemokine receptors, and this selection is thought to be vital for its job as a CC chemokine antagonist.

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6 kcal mol−1 ). 0 kcal mol−1 was obtained for ion–molecule complexes with water42 . The mechanism of the forward and reverse reaction of HOOž radical with NO has also been examined at the B3LYP/6-311+G(3df,2p) level43 . The dominant pathway for the formation of HO + NO2 from the reaction of these two radicals involves the direct fragmentation of intermediate HO−ONO. 2 kcal mol−1 higher in energy. The reaction between hydroxyl radical and NO2 has also been characterized by Dolco and R¨othlisberger44 using the B3LYP method.

9 kcal mol−1 at 298 K. 4 kcal mol−1 at 298 K. According to classical transition state theory, the branching ratio for the reaction in its triplet state multiplicity changes from negligible at 298 K to about 26% at 1800 K, and this ratio equals the formation of atomic oxygen, O(3 P). 5 kcal mol−1 77b .

Energy diagram (kcal mol−1 ) for the O−O bond elongation of cis- and trans-HO−ONO to form their respective higher-lying singlet biradicaloid minima. Plain numbers are at the UB3LYP/ 6-311+G(3df,2p) level. Bold numbers correspond to UQCISD(T)/6-311+G(d,p)//UQCISD/6-311+ G(d,p). 17 A than its cis-peroxynitrous acid GS precursor (Figure 2, cis-2). 8 kcal mol−1 higher in energy than ground-state HO−ONO. 7 kcal mol−1 higher in energy than GS cis-HO−ONO, in excellent agreement with the DFT calculations.

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CC Chemokine of Molluscum Contagiosum Virus by McFadden G., Moyer R.


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