Download PDF by Claudiu T Supuran, Giuseppina De Simone: Carbonic Anhydrases as Biocatalysts: From Theory to Medical

By Claudiu T Supuran, Giuseppina De Simone

ISBN-10: 0444632581

ISBN-13: 9780444632586

Carbonic anhydrases (CAs, EC 4.2.1.1) are ubiquitous metalloenzymes, current all through so much residing organisms and encoded through 5 evolutionarily unrelated gene households. The Carbonic Anhydrases as Biocatalysts:From thought to clinical and commercial Applications offers info at the transforming into curiosity within the examine of this enzyme relatives and their functions to either medication and biotechnology.

  • Offers complete insurance of the carbonic anhydrases enzyme relations and their homes as biocatalysts
  • Includes present purposes of carbonic anhydrases in biotechnology at the foundation in their catalytic potency, together with new applied sciences for CO2 catch processes
  • Identifies new objectives for drug layout studies
  • Provides a selectivity profile for the several carbonic anhydrases and their comparable biomedical applications

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Extra resources for Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications

Sample text

14. Kumar V, Kannan KK, Sathyamurthi P. Differences in anionic inhibition of human carbonic anhydrase I revealed from the structures of iodide and gold cyanide inhibitor complexes. Acta Crystallogr D Biol Crystallogr 1994;50:731–8. 15. Kannan KK. Structure and function of carbonic anhydrases. Biomol Struct Conformation Funct Evol 1981;1:165–81. 16. Ferraroni M,Tilli S, Briganti F. Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: evidence for a second zinc binding site involving arginine coordination.

74. Winum J-Y, Rami M, Scozzafava A, Montero J-L, Supuran CT. Carbonic anhydrase IX: a new druggable target for the design of antitumor agents. Med Res Rev 2008;28:445–63. 75. Thiry A, Dogné JM, Supuran CT, Masereel B. Anticonvulsant sulfonamides/sulfamates/sulfamides with carbonic anhydrase inhibitory activity: drug design and mechanism of action. Curr Pharm Des 2008;14:661–71. 29 30 Carbonic Anhydrases as Biocatalysts 76. Räisänen SR, Lehenkari P, Tasanen M, Rahkila P, Härkönen PL,Väänänen HK.

Boriack-Sjodin PA, Heck RW, Laipis PJ, Silverman DN, Christianson DW. 45 Å resolution: implications for catalytic proton transfer and inhibitor design. Proc Natl Acad Sci U S A 1995;92:10949–53. 44. Alterio V, Hilvo M, Di Fiore A, Supuran CT, Pan P, Parkkila S, et al. Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX. Proc Natl Acad Sci U S A 2009;106: 16233–8. 45. Whittington DA, Waheed A, Ulmasov B, Shah GN, Grubb JH, Sly WS, et al. Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells.

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Carbonic Anhydrases as Biocatalysts: From Theory to Medical and Industrial Applications by Claudiu T Supuran, Giuseppina De Simone


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