Download PDF by Jatin P. Shah, Snehal G. Patel, Alice Y. Chen: Cancer of the Head and Neck (Acs Atlas of Clinical Oncology)

By Jatin P. Shah, Snehal G. Patel, Alice Y. Chen

ISBN-10: 1550090844

ISBN-13: 9781550090840

Dr. Jatin P. Shah has introduced jointly contributing authors in one quantity that represents the top and neck administration staff at Memorial Sloan-Kettering melanoma middle. The power of the amount is in it truly is inner consistency of diagnostic techniques, healing judgements, multidisciplinary therapy courses, and surgical strategies. An attempt has additionally been made to be accomplished and to offer a balanced view to different remedy ways. This e-book follows the ACS and American Head and Neck Society instructions, focusing totally on consequence research and implementation of facts established drugs. those have proved very good directions for the practitioner in the neighborhood and are swiftly turning into criteria of care. necessary to the analysis and remedy of the sickness is the involvement of a multidisciplinary administration workforce of medical examiners. Such disorder administration groups increase remedy algorithms and determine remedy directions to unify an method of preserve inner consistency, begin investigative protocols, and push the frontiers within the conflict opposed to melanoma.

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Additional info for Cancer of the Head and Neck (Acs Atlas of Clinical Oncology)

Sample text

Los melanocitos migran hacia el tracto uveal del ojo (iris y coroides), la cóclea del oído interno y las leptomeninges, además de a la epidermis y al folículo piloso. La retina en realidad representa una prolongación del tubo neural. (Adaptada de Bolognia JL y cols. Dermatology. ) precursores de melanocitos (los melanoblastos) que emigran a lo largo de la vía dorsolateral entre el somita y el ectodermo suprayacente hacia la dermis y, por último, alcanzan su destino final en la epidermis y en los folículos pilosos.

Las proteínas RAF ejercen su función después que las RAF, por lo que en teoría, las mutaciones en el gen RAF tienen el mismo efecto en la activación de la vía MAPK que las mutaciones del RAS. Por tanto, las mutaciones en ambos genes pueden ser importantes en la patogenia del melanoma maligno cutáneo. 100 describieron que un 66% de las muestras de melanoma estudiadas tenían mutaciones BRAF. 5 Vía de señalización RAS/RAF. Por lo general, la RAS se activa a través de la estimulación de receptores de la superficie celular tirosincinasa, receptores acoplados a proteína G, o receptores de adhesión celular integrina, para desencadenar la señal de traducción a través de varias vías efectoras.

La progresión del ciclo celular desde la fase G1 depende de un complejo molecular formado por la ciclina D1 y CDK4 (cinasa dependiente de ciclina 4). El componente CDK4 de este complejo fosforila el producto del gen supresor tumoral del retinoblastoma (Rb), que libera factores de transcripción de la familia E2F. Una vez que se liberan los factores de transcripción E2F por Rb, se induce la expresión de genes necesarios para salir de G1 y avanzar hacia la fase S del ciclo celular. Para inhibir la progresión del ciclo celular, la proteína p16INK4A se une a CDK4 e inhibe su actividad cinasa, por lo que, si la fosforilación de la proteína Rb está alterada, la proteína Rb hipofosforilada no libera los factores de transcripción E2F y el ciclo celular se detiene en tificación de aberraciones cromosómicas recurrentes en los análisis extensos del genoma de carcinomas epidermoides.

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Cancer of the Head and Neck (Acs Atlas of Clinical Oncology) by Jatin P. Shah, Snehal G. Patel, Alice Y. Chen


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