Get Cancer Drug Resistance (Cancer Drug Discovery and PDF

By Beverly A. Teicher

ISBN-10: 1588295303

ISBN-13: 9781588295309

Major specialists summarize and synthesize the newest discoveries about the adjustments that ensue in tumor cells as they improve resistance to anticancer medicines, and recommend new methods to fighting and overcoming it. The authors evaluation physiological resistance dependent upon tumor structure, mobile resistance in accordance with drug delivery, epigenetic adjustments that neutralize or pass drug cytotoxicity, and genetic alterations that modify drug goal molecules via lowering or doing away with drug binding and efficacy. Highlights contain new insights into resistance to antiangiogenic treatments, oncogenes and tumor suppressor genes in healing resistance, melanoma stem cells, and the improvement of greater remedies. There also are new findings on tumor immune get away mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.

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Patan S, Munn LL, Jain RK. Intussusceptive microvascular growth in a human colon adenocarcinoma xenograft: a novel mechanism of tumor angiogenesis. Microvasc Res 1996; 51:260–272. 16. Burri PH, Hlushchuk R, Djonov V. Intussusceptive angiogenesis: its emergence, its characteristics, and its significance. Dev Dyn 2004; 231:474–488. 17. Folkman J. Angiogenesis and angiogenesis inhibition: an overview. EXS 1997; 79:1–8. 18. Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF.

Furthermore, the thermal survival curves of cells adapted and unadapted to a low-pH environment were identical when the survival curves were plotted against pHi instead of pHe. Chu and Dewey (114) therefore concluded that the increase in pHi was the reason why cells that adapted to a low-pH environment were resistant to heat at low pHe relative to the unadapted cells. van der Berg et al. (117) reported that the thermosensitivity of human tumors showing an acidic interstitial pH was not necessarily greater than the thermosensitivity of tumors showing neutral interstitial pH.

56. Dewhirst MW, Ong ET, Braun RD, et al. Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia. Br J Cancer 1999; 79:1717–1722. 57. Secomb TW, Hsu R, Braun RD, Ross JR, Gross JF, Dewhirst MW. Theoretical simulation of oxygen transport to tumors by three-dimensional networks of microvessels. Adv Exp Med Biol 1998; 454:629–634. 58. Dewhirst MW, Secomb TW, Ong ET, Hsu R, Gross JF. Determination of local oxygen consumption rates in tumors. Cancer Res 1994; 54:3333–3336.

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Cancer Drug Resistance (Cancer Drug Discovery and Development) by Beverly A. Teicher

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