By Beverly A. Teicher
Major specialists summarize and synthesize the newest discoveries about the adjustments that ensue in tumor cells as they improve resistance to anticancer medicines, and recommend new methods to fighting and overcoming it. The authors evaluation physiological resistance dependent upon tumor structure, mobile resistance in accordance with drug delivery, epigenetic adjustments that neutralize or pass drug cytotoxicity, and genetic alterations that modify drug goal molecules via lowering or doing away with drug binding and efficacy. Highlights contain new insights into resistance to antiangiogenic treatments, oncogenes and tumor suppressor genes in healing resistance, melanoma stem cells, and the improvement of greater remedies. There also are new findings on tumor immune get away mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
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Extra resources for Cancer Drug Resistance (Cancer Drug Discovery and Development)
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Cancer Drug Resistance (Cancer Drug Discovery and Development) by Beverly A. Teicher