By Michael Torbenson MD
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Extra info for Biopsy Interpretation of the Liver
Holve S, Hu D, Shub M, et al. Liver disease in Navajo neuropathy. J Pediatr. 1999; 135(4):482–493. 38. Krähenbühl S, Kleinle S, Henz S, et al. Microvesicular steatosis, hemosiderosis and rapid development of liver cirrhosis in a patient with Pearson’s syndrome. J Hepatol. 1999;31(3):550–555. 39. Bioulac-Sage P, Parrot-Roulaud F, Mazat JP, et al. Fatal neonatal liver failure and mitochondrial cytopathy (oxidative phosphorylation deficiency): a light and electron microscopic study of the liver. Hepatology.
Selective zone 2 necrosis is also very rare. The differential includes rare poisons such as ngaione, heavy metals such as beryllium, and rare viral infections such as yellow fever virus. Of note, both the zone 1 and the zone 2 patterns of liver necrosis are sufficiently rare that many associations are based on data limited to a small set of case reports. Vascular Injury Pattern Vascular injury is discussed in detail in Chapter 13, but a useful conceptual framework is to think of vascular injury as having several major patterns.
Mahler H, Pasi A, Kramer JM, et al. Fulminant liver failure in association with the emetic toxin of Bacillus cereus. N Engl J Med. 1997;336(16):1142–1148. 48. Pereira FE, Musso C, Lucas-Ede A. Labrea-like hepatitis in Vitoria, Espirito Santo State, Brazil: report of a case. Rev Soc Bras Med Trop. 1993;26(4):237–242. 49. Andrade ZA, Lesbordes JL, Ravisse P, et al. Fulminant hepatitis with microvesicular steatosis (a histologic comparison of cases occurring in Brazil—Labrea hepatitis—and in central Africa—Bangui hepatitis).
Biopsy Interpretation of the Liver by Michael Torbenson MD