Bioassay Methods in Natural Product Research and Drug by T. Elmqvist (auth.), Lars Bohlin, Jan G. Bruhn (eds.) PDF

By T. Elmqvist (auth.), Lars Bohlin, Jan G. Bruhn (eds.)

ISBN-10: 9401060193

ISBN-13: 9789401060196

ISBN-10: 9401148104

ISBN-13: 9789401148108

Bioassay tools in traditional Product learn and Drug Development comprises the lawsuits from the Phytochemical Society of Europe's very winning symposium in this subject, held August 24-27, 1997 in Uppsala, Sweden.
during this quantity, prime educational and business scientists speak about novel tools for assaying usual items to discover new structure-activity relationships. Of key value during this procedure is the supply and reliability of particular bioassay equipment, yet chapters additionally talk about chemical and organic variety and the way to dereplicate traditional product extracts to extend potency in lead discovery.
Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory common items are mentioned. a number of commercial tasks are offered for the 1st time.
This quantity bridges the distance among educational and commercial study and scientists, and will be required interpreting in drug businesses and schools of pharmacy, in addition to serving scientists in pharmacognosy, pharmacology, phytochemistry, ordinary items and drug discovery.

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Toxic substances might indeed elicit, at lower non-toxic dose, interesting pharmacological effects [11]. The second technique is the inhibition of the development of crown gall tumours on discs of potato tubers [13]. Crown-gall is a neoplastic disease induced by the gram-negative bacterium Agrobacterium tumefaciens, a bacterium known to infect a number of crop plants, and is due to the transfer of a tumour-inducing plasmid from the bacterium in the plant genome. The bioassay is fairly accurate in predicting 3PS (P388) in vivo murine antileukemic activity.

Other enzyme assays, which have been used for the screening of natural substances include monoamine oxidase (antidepressant activity), H+/K+-ATP-ase (anti-gastric ulcer activity), polysaccharide degrading enzymes (amylase, glucosidase) and aldose reductase (anti-diabetic activity) HMG-CoA reductase (anti-atherosclerotic activity), Sa-reductase (anti-androgenic activity), and xanthine oxidase (anti-oxydative activity). The inhibitory activity of the test compooods is mostly determined after chromatographic separation of the enzymatic reaction products by means of UV or fluorescence spectrophotometric detection.

11. Comparative studies of sulfated sterols from marine invertebrates. J. Med. Chem. 37: 793-797, 1994. L. R: AIDS-antiviral sulfolipids from cyanobacteria (blue-green algae). J. Natl. Cancer Inst. 58, 1989. M. R: Cytotoxic quassinoids from Cedronia granalensis Cautrec. J. Nat. Prod. 55: 667-671, 1992. M. R: The differential cytotoxicity of cardenolides from Thevetia ahouUz. Phytother. Res. 8: 74-77, 1994. M. R: Cucurbitacins: differential cytotoxicity, dereplication and first isolation from Gonystylus keithii.

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Bioassay Methods in Natural Product Research and Drug Development by T. Elmqvist (auth.), Lars Bohlin, Jan G. Bruhn (eds.)


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