By Dr. G. M. Kostner (auth.), Dr. Maryvonne Rosseneu, Prof. Dr. Kurt Widhalm, Dr. Jochen Jarausch (eds.)
There is expanding proof for the clinicial price of the apo lipoprotein measurements. along with ldl cholesterol in plasma and li poprotein fractions, that's presently used as a hallmark of cardiovascular chance, the dimension of the AI and B apolipopro teins supplies additional info concerning the sufferers' medical prestige. a number of reviews express that apo B is better and apo AI is decrease in sufferers with angiographically documented heart dis ease than in symptomatic sufferers with no heart illness. in addition, discriminant research indicated that the focus of Apo AI and B in plasma are higher discriminators than lipo protein ldl cholesterol for settling on sufferers with heart affliction. In a few reviews the apo Bjapo AI ratio seems to be a extra strong predictor than person lipoproteins. In a contemporary learn conducted in males, apolipoproteins AI and B have been larger correlated with the severity of heart problems than HDL and cholesterol. The predictive energy of apolipoproteins may possibly even though now not be tested in all reports and the worth of apolipoprotein measurements within the box of scientific chemistry remains to be debatable. this can be most likely because of discrepancies among the result of a variety of reports, bobbing up from adjustments within the form of immunoassays, the inability of common reference fabrics, vary ences among research protocols, adaptations within the collection of sufferers and within the grading and interpretation of coronary lesions.
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Extra info for Apolipoproteins in Lipid Disorders: Risk Assessment and Monitoring
Deslypere References 1. Assmann G (ed) (1989) Lipid metabolism disorders and coronary heart disease. MMV Medizin Verlag, Miinchen 2. Avogaro P, Bittolo Bon G, Cazzalato G (1979) Are apolipoproteins better discriminators than lipids for atherosclerosis? Lancet i: 901-903 3. Avogaro P, Bittolo Bon G, Cazzolato G, Rovai E (1980) Relationship between apolipoproteins and chemical components of lipoproteins in survivors of myocardial infarction. Atherosclerosis 37: 69-76 4. Barbir M, Wile D, Trayner I, Aber VR, Thompson GR (1988) High prevalence of hypertriglyceridemia and apolipoprotein abnormalities in coronary artery disease.
Acta Cardiol 27: 95-102 12. Durrington PN, Hant L, Ishola M, Kane J, Stephens WP (1986) Serum apolipoproteins AI and B and lipoproteins in middle aged men with and without previous myocardial infarction. Br Heart J 56: 206-212 13. Freedman DS, Srinivasan SR, Shear CL, Franklin FA, Webber LS, Berenson GS (1986) The relation of apolipoproteins AI and B in children to parenteral myocardial infarction. N Engl J Med 315: 721-726 14. Gordon DJ, Rifkind B (1989) High density lipoprotein - the clinical implications of recent studies.
1). Furthermore, a significant association between the percentage of total surface involvement of the coronary arteries with fatty streaks and the VLDL concentration could be shown. Thus, although within a relatively small group of subjects, there exists some evidence that the concentration of certain lipoproteins is more directly associated to clinical disease than the corresponding concentrations of lipoprotein cholesterol fractions alone . In addition, elevated levels of LDL apo B without an increase of LDL-C - a condition termed hyperapobetalipoproteinemia - may be associated with the development of cardiovascular disease .
Apolipoproteins in Lipid Disorders: Risk Assessment and Monitoring by Dr. G. M. Kostner (auth.), Dr. Maryvonne Rosseneu, Prof. Dr. Kurt Widhalm, Dr. Jochen Jarausch (eds.)