By G. Da Silva Xavier
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2010). , 2011). , 2011). , 2009). The different mechanisms by which STAT3 and NF-B (predominantly the RelA/p50 heterodimer) interact to enhance target gene transcription have been shown to be context-dependent but typically result in enhanced target gene induction. For example, Tyr705-phosphorylated STAT3 has been shown to bind promoter-bound RelA to facilitate the recruitment of the transcriptional co-activator p300, thereby triggering RelA acetylation. , 2009). , 2007). , 2007; Yang & Stark, 2008).
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S. (1997) The protein tyrosine phosphatase SHP-2 negatively regulates ciliary neurotrophic factor induction of gene expression, Curr Biol. 7: 697-700. , Parganas, E. & Ihle, J N. SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation, EMBO J. 22: 372-384. , Hibi, M. & Hirano, T. (1998) Gab1 acts as an adapter molecule linking the cytokine receptor gp130 to ERK mitogen-activated protein kinase, Mol Cell Biol. 18: 4109-4117. , Förster, I. & Akira, S. (1999) Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils, Immunity.
Advances in Protein Kinases by G. Da Silva Xavier