By Horace W. Davenport
This publication examines the heritage of experimental learn in gastric secretion and digestion. the writer identifies the clinical questions that experience occupied researchers and discusses the experiments that experience resulted in their suggestions. by way of separating features of experimental examine and tracing their evolution through the years, the e-book presents gastric physiologists and gastroenterologists with a great knowing of the highbrow heritage in their box.
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Extra resources for A History of Gastric Secretion and Digestion: Experimental Studies to 1975
I could not directly determine the activity coefficients, but I knew that Willard Gibbs bad said that the chemical potential of a solute in a saturated solution is equal to its chemical potential in the solid phase. Plasma can be saturated with a sulfonamide drug and its saturating concentration measured. Likewise, an acid solution whose hydrogen ion concentration is equal to that of gastric juice can be saturated with the same drug and the saturating concentration measured. Because the chemical potential in each solution is equal tothat ofthe solid phase, the chemical potentials ofthe drugs in solution are equal to each other.
Cl· .. 0 ' .... : . •• m 1 · ·. ·· g· 0 0 . · .. · . H. : .. ·. ·:. B. ·:· 0 . • 0 0 ... ·. ·. · OTSftiC " 1': •cids ..... ··. :· 0 •• sif •• 0 ·:·· .... · 0 0 0 •• 0 •• 0 •• •• 0 0 .... Ti! Pl ~ 0 ••• .... • 0 .. I • 0 ·.. · .. ·. 1 N PER. · .. ... · IITI :·;:: DURINEJ • 0 • DIGESTION OF FOOD. SECRETIONS .. ·. 0 : 0 MORNIN& SPECIMENS. FROM F"UNDUS. ·· 0 ... ·.... :. ·. :. ·.. · .... :.. 0 0 0 0 0 0 .. ·· 0 SECRETIONS FROM PYLORJC ANiRUM. 0 . :. : 0 •• II HP04 •• BLOOD PLASMA. Figure 1-7.
78 mM thiocyanate; ordinates, concentration of inactive carbonic anhydrase in the solution in the same arbitrary units. e oxyntic cells calculated as described in the text; ordinates, hydrogen ion concentration in gastric juice as a percentage of uninhibited concentration under maximal histamine Stimulation. The dotted line is the regression line calculated from the data. The solid line is the theoreticalline derived from the assumptions described in the text. (From Davenport HW. The inhibition of carbonic anhydrase and of gastric acid secretion by thiocyanate.
A History of Gastric Secretion and Digestion: Experimental Studies to 1975 by Horace W. Davenport