By Hamish Denny, Steve Butterworth
Authoritative consultant to developments in small animal orthopaedic surgical procedure. offers a finished evaluate of orthopaedic and spinal stipulations within the puppy or cat. features a local method of difficulties that permits the reader to exploit it as a speedy reference. Illustrations. for college students taking extra skills in orthopedics and veterinarians. past variation: cc1993.
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Extra info for A Guide to Canine and Feline Orthopaedic Surgery
Very early changes in the cartilage. Whilst MRI promises to become the gold standard in imaging joints, there are problems with resolution and also defining the calcified zone of articular cartilage. Biochemical markers of joint disease Much research is concentrating on biochemical methods to detect changes in joint tissues. The hope is that these tests will allow changes to be Osteoarthritis detected early and allow targeting of patients for disease-modifymg therapy. They might also allow the effectiveness of such treatments to be monitored.
Thus, there is much conflicting evidence in the literature. At present there is only one drug in this class licensed for use in the dog. This is sodium pentosan polysulphate (PPS) (Cartrophen-Vet, Arthropharm, Australia) which is a polysaccha- 61 ride sulphate ester prepared from beech hemicellulose. The mode of action in clinical cases is obscure and recent studies suggest that the fibrinolytic action may shift microthrombi in the vascular supply of subchondral bone resulting in pain relief. Validated clinical trials with the drug are lacking but anecdotal evidence suggests that it can give impressive clinical results in certain cases.
The role of crystals in canine OA is unexplored. Whether this erosive change represents a different subset of OA or merely one end of a spectrum of change remains unclear. However, it emphasises the need for further diagnostic work apart from radiography. Erosive changes in a joint may be seen 56 Chapter7 also in diseases such as rheumatoid arthritis and infectious arthritis. However,in cases of secondary OA signs may be related mainly to the underlying disease. It is important to remember that the course of OA is variable with some osteoarthritic joints remaining clinically silent and non-progressive, and some being very painful and rapidly progressive.
A Guide to Canine and Feline Orthopaedic Surgery by Hamish Denny, Steve Butterworth